Access evidence‑based infant feeding guidance, clinical resources and Aptamil product information to support your work with infants and young children.
Babies deserve the highest standards. Made with care.
How does Aptamil's science and ingredients compare with other formulas?
Aptamil First Infant Milk
Kendamil First Infant Milk
SMA Nestle First Infant Milk
Hipp Organic First Infant Milk
Cow & Gate First Infant Milk
Aptamil's product range
- Aptamil
- Advanced
- Reflux
- Colic
Aptamil First Infant Milk with prebiotics and postbiotics:
Supports the immune system through the gut (1-3):
- Stool consistency significantly softer (p<0.05) than infants fed a standard formula4
- Closer to stool consistency of breastfed infants4
- Ensures normal growth according to WHO standards4
- Safe and well-tolerated4
Key Ingredients
- Prebiotics: scGOS/lcFOS,clinically proven to bring the gut microbiota closer to that of a breastfed infant5,6
- Postbiotics: LactofidusTM
Aptamil Advanced is our most advanced formulation yet
Research has shown that 2’-FL has gut and immune benefits including blocking growth of pathogens in the gut and parents reported fewer respiratory infections in infants7-9
Key Ingredients
- HMO: 2’FL, the most abundant HMO in breastmilk, to support the immune system7-10
- Prebiotics: scGOS/lcFOS, clinically proven to bring the gut microbiota closer to that of a breastfed infant5,6
- Phospholipid-bound LCPs similar to what is found in breastmilk11-12 - no other infant formula contains this
- C16:0 milk fat – provides a better profile of fatty acids, closer to that of breastmilk13-14
Aptamil Anti-Reflux is effective and clinically proven for infants with reflux and regurgitation (15, 16)
- Clinically proven to reduce regurgitation episodes (p<0.001) and improve severity scores (p<0.001)15
- Significant decrease in crying times (p<0.001)15
- High parental satisfaction (infant acceptance of formula & improved wellbeing)15
- Formula was safe, well tolerated & supported adequate growth15
Key Ingredients
- Prebiotics: Clinically proven to increase bifidobacteria levels, which supports gut microbiota balance and soften stools5,6.
- Postbiotics: LactofidusTM
- Thickened with carob bean gum, a plant-derived thickener that helps to normalise oesophageal pH17 and provide a greater viscosity in the stomach vs starch-based feeds18
Aptamil Comfort is effective and clinically proven for infants with colic and constipation (19, 20)
- Significant reduction in daily episodes of colic within 1 week19,20
- Significant reduction in crying episodes after 1 week20
- Significant increase in daily number of stools within 1 week19
Key Ingredients
- Prebiotics: scGOS/lcFOS: Clinically proven to increase bifidobacteria levels, which supports gut microbiota balance and soften stools5,6
- Partially hydrolysed whey protein: Easy to digest21,22
- Reduced lactose: May help reduce flatulence and abdominal discomfort23,24
- Fat blend containing beta-palmitate: Promotes softer stools and aids the absorption of fat and calcium25-27
Aptamil have been at the forefront of advanced breastmilk research for over 50 years.
Our journey of discovery
How Aptamil's science goes into every drop
From breastmilk research to breakthrough ingredients, see how science guides everything we do - helping you make confident feeding choices.
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The comparison chart provides data on selected information. All product comparisons are based on the 800g powder format. Refer to product datacards/websites for more information. Information correct April 2026.
Postbiotics: from fermentation process.
All Aptamil standard milk powder is manufactured in Ireland.
scGOS: Short Chain Galacto-Oligosaccharides; IcFOS: Long Chain Fructo-Oligosaccharides;
- Wopereis H et al. Pediatr Allergy Immunol. 2014;25:428–438. 6.
- Martin R et al. Benef Microbes. 2010;1:367–382.
- Aguilar-Toala JE et al. Trends Food Sci Technol. 2018;75:105–114
- Rodriquez-Herrera A et al. Nutrients. 2019;11(7), 1530.
- Knol J, et al. J Pediatr Gastroenterol Nutr. 2005;40(1):36-42. 20.
- Moro G, et al. J Pediatr Gastroenterol Nutr. 2002;34:291-5.
- Reverri EJ et al. Nutrients, 2018;10(10):1346.
- Weichert S et al. Nutr Res, 2013;33:831-8.
- Yu ZT et al. Nutr, 2016;146:1980-90.
- Goh CY, et al. J Pediatr Gastroenterol Nutr; 2019
- Harzer G et al., Am J Clin Nutr. 1983;37(4):612-21.
- Willatts P et al., Lancet, 1998. 352(9129):688-91
- Dolplanque B et al. J Pediatr Gastroenterol Nutr, 2015;61:8-17
- Carnielli VP et al. J Pediatr Gastroenterol Nutr. 1996;23(5):553-60
- Bellaiche, et al. Pediatr Gastroenterol Hepatol Nutr. 2023; 26(5):249-65.
- Wenzl TG, et al. J Pediatr. 2003;111(4): e355–e359.
- Vandenplas, et al. Eur J Pediatr 1994;153:419-23.
- Nutricia Research Artificial digestion model.[Data on file].
- Savino, et al. Acta Paediatr Suppl. 2003;91(441):86-90.
- Savino, et al. Eur J Clin Nutr 2006;60:1034-10.
- Billeaud, et al. Eur J Clin Nutr. 1990;44(8):577-83.
- Tolia, et al. J Pediatr Gastroenterol Nutr. 1992;15(3):297-301.
- Kanabar, et al. J Hum Nutr Diet. 2001;14(5):359-63.
- Miller, et al. Arch Dis Child 1989;64:725-9.
- Havlicekova, et al. Nutr J. 2015;15(1):28.
- Carnielli, et al. Am J Clin Nutr. 1995;61(5):1037-42.
- Kennedy, et al. Am J Clin Nutr 1999;70:920–7.
- Staemmler et al. Medizin and Ernaehrung 10, 12 (1971): 220-223.
- Wemmer U. Meb Fortschr Med 1977;95(7):441-6; 3. Harzer G, et al. Am J Clin Nutr 1983;37(4), 612-21.
- Stahl B, et al. Anal Biochem 1994;223(2), 218-26.
- Martin R, et al. J Pediatr 2003;143(6), 754-58.
- Thurl S, et al. Br J Nutr 2010;104:1261–71.
- Coppa GV, et al. JPGN. 2011.
- van Herwijnen MJ, et al. Mol Cell Proteomics 2016;15(11):3412-23.
What if parents or carers need more support?
Parents have access to our dedicated Careline for evidence-based information and advice from trained professionals, including midwives, dietitians, and feeding advisors for guidance
IMPORTANT NOTICE: Breastfeeding is best. Infant milk is suitable from birth, when babies are not breastfed. We advise that all formula milks be used on the advice of a doctor, dietitian, pharmacist or other professional responsible for maternal and child care. Foods for Special Medical Purposes should only be used under medical supervision. May be suitable for use as the sole source of nutrition for infants from birth, and/or as part of a balanced diet from 6-12 months. Refer to label for details.
